fingolimod派克大衣国内那里有卖有卖吗

来源：蜘蛛抓取(WebSpider) 时间：2017-02-07 09:26 标签： polham国内有专卖店吗
Fingolimod的生物活性
Fingolimod(FTY720& free base) is a S1P antagonist with IC50 of 0.033 nM.
Target: S1P
Fingolimod(FTY720& free base) is a S1P antagonist with IC50 of 0.033 nM. The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. In addition, FTY720 (10 nM) alone exerts no effect on the expression of co-stimulatory molecules. FTY720 reverses the increased expression of HLA-I induced by S1P for both the percentages of cells and the MFI, upon comparing the effect of S1P to the effect of combining S1P with FTY720 [1]. Medium and high-dose FTY720-P also enhances the levels of TGF-&1. TGF-&1 and Foxp3 mRNA expression are upregulated in the high-dose FTY720-P group. The proliferation of effector T cells is suppressed significantly in the medium and high-dose FTY720-P group at a Treg/Teff cell ratio of 1:1. At a ratio of 1:1, the proliferation of effector T cells is also suppressed in the high-dose FTY720 group [2].
FTY720 is effective in Ph+ but not Ph- ALL xenografts using an early disease model. FTY720 produces a significant reduction in disease burden in the Ph+ ALL xenografts using an early disease model. Ph+ human ALL xenografts responds to FTY720 with an 80 % reduction in overall disease if treatment has been initiated early on. In contrast, treatment of mice with FTY720 does not result in reduced leukemia compared to controls using four separate human Ph- ALL xenografts [3].
参考CoA中推荐的条件进行储存。
溶剂/溶解度
10 mM in DMSOFingolimod hydrochloride的生物活性
Fingolimod Hcl (FTY720) is a S1P antagonist with IC50 of 0.033 nM.
IC50 value: 0.033 nM
Target: S1P
in vitro: The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. In addition, FTY720 (10 nM) alone exerts no effect on the expression of co-stimulatory molecules. FTY720 reverses the increased expression of HLA-I induced by S1P for both the percentages of cells and the MFI, upon comparing the effect of S1P to the effect of combining S1P with FTY720 [1]. Medium and high-dose FTY720-P also enhances the levels of TGF-&1. TGF-&1 and Foxp3 mRNA expression are upregulated in the high-dose FTY720-P group. The proliferation of effector T cells is suppressed significantly in the medium and high-dose FTY720-P group at a Treg/Teff cell ratio of 1:1. At a ratio of 1:1, the proliferation of effector T cells is also suppressed in the high-dose FTY720 group [2].
in vivo: FTY720 is effective in Ph+ but not Ph- ALL xenografts using an early disease model. FTY720 produces a significant reduction in disease burden in the Ph+ ALL xenografts using an early disease model. Ph+ human ALL xenografts responds to FTY720 with an 80 % reduction in overall disease if treatment has been initiated early on. In contrast, treatment of mice with FTY720 does not result in reduced leukemia compared to controls using four separate human Ph- ALL xenografts [3].
参考CoA中推荐的条件进行储存。
C??H??ClNO?
溶剂/溶解度
10 mM in DMSO细胞库/细胞培养
ELISA试剂盒
实验室仪器/设备
原辅料包材
体外检测试剂
&&Fingolimod
Fingolimod
&丁香通采购保障计划，让您的采购更放心。
供应商信息
商家诚信度：
成立时间：2009年
入驻丁香通年限：3年
商家等级：金牌客户
产品信息完整度：68%
联系人：高小姐
若您通过QQ未能联系到商家，您可以给商家发送站内信，与其取得联系。
扫一扫微信联系商家
电话：021-
传真：021-
地址：上海市张江高科技园区蔡伦路720弄2号303室
该商家已通过实名认证
数据正在加载，请稍候...
扫一扫微信联系商家
电话: 021-
联系人: 高小姐
（联系我时请说在丁香通看到的）
30秒填写信息，方便商家与您及时沟通
您正在向&&发送关于产品&&的询问
登录丁香园账号即可使用多地址管理，
*&电话和Email请至少填写一项
给商家留言
我对您在丁香通发布的“Fingolimod” 非常感兴趣。请联系我并提供报价。
点击“立即发送”后，商家将在1个工作日内与您取得联系。
让更多商家看到我的询价
丁香通采购热线：400-
Copyright (C)
DXY All Rights Reserved.

我要回帖

更多关于 polham国内有专卖店吗 的文章

 

随机推荐