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我的位置：&>>>>>>CR1 complement component (3b/4b) receptor 1 (Knops blood group) [Homo sapiens (human)] - Gene - NCBI
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CategoriesSequence contentStatusChromosome locationsFromToApply
FormatFull ReportFull Report (text)Gene TableGene Table (text)GeneRIFSummarySummary (text)TabularTabular (text)ASN.1XMLUI ListApplyChoose DestinationFileClipboardCollectionsFormatFull Report (text)Gene Table (text)Summary (text)Tabular (text)ASN.1XMLUI ListCreate FileAdd to ClipboardAdd to Collections
CR1provided by
complement component (3b/4b) receptor 1 (Knops blood group)provided by
Primary source
See related
protein coding
RefSeq status
E M C C V E M E E P H C H Homo
Also known as
KN; C3BR; C4BR; CD35
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
See CR1 in
Annotation release
GRCh38.p2 ()
previous assembly
GRCh37.p13 ()
Chromosome 1 - NC_
Genomic Sequence:
NC_ Chromosome 1 Reference GRCh38.p2 Primary Assembly
NG_ RefSeqGene
NC_ Chromosome 1 Alternate CHM1_1.1
NC_ Chromosome 1 Reference GRCh37.p13 Primary Assembly
Go to nucleotide:
Related articles in PubMed
GeneRIFs: Gene References Into Functions
Title: Differential complement activation pathways promote C3b deposition on native and acetylated LDL thereby inducing lipoprotein binding to the complement receptor 1.
Title: Meta-analysis of the association between CR1 polymorphisms and risk of late-onset Alzheimer's disease.
Title: CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease.
Title: Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects.
Title: Complement receptor 1 expression in peripheral blood mononuclear cells and the association with clinicopathological features and prognosis of nasopharyngeal carcinoma.
Title: Tag SNPs in complement receptor-1 contribute to the susceptibility to non-small cell lung cancer.
Title: Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria.
Title: Leucocyte complement receptor 1 (CR1/CD35) transcript and its correlation with the clinical disease activity in rheumatoid arthritis patients.
Title: Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor.
Title: Maternal coding variants in complement receptor 1 and spontaneous idiopathic preterm birth.
not available
GeneReviews: Not available
NHGRI GWAS Catalog
Description
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.NHGRI GWA Catalog
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.NHGRI GWA Catalog
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.NHGRI GWA Catalog
Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate.NHGRI GWA Catalog
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.NHGRI GWA Catalog
Protein interactions
Interaction
HIV-1 gp120 downregulates the expression of complement component receptor 1 (CR1) in human B cells
HIV-1 Tat downregulates the expression of complement component (3b/4b) receptor 1 (CR1; CD35) in human primary T cells
SHGC-35372 (e-PCR)
D1S2538 (e-PCR)
RH11128 (e-PCR)
SHGC-35375 (e-PCR)
D8S2279 (e-PCR)
AL034227 (e-PCR)
SHGC-33387 (e-PCR)
D1S2796 (e-PCR), detects polymorphism
L17971 (e-PCR)
D1S2782 (e-PCR), detects polymorphism
Inferred from Direct Assay
Inferred from Direct Assay
Inferred from Direct Assay
Evidence Code
Inferred from Electronic Annotation
Inferred from Direct Assay
Traceable Author Statement
Inferred from Direct Assay
Inferred from Direct Assay
Inferred from Direct Assay
Inferred from Direct Assay
Traceable Author Statement
Evidence Code
Inferred from Direct Assay
Inferred from Direct Assay
Inferred from Direct Assay
Traceable Author Statement
Preferred Names
complement receptor type 1
complement receptor type 1
C3-binding protein
C3b/C4b receptor
CD35 antigen
Knops blood group antigen
These reference sequences exist independently of genome builds.
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in
NG_ RefSeqGene
mRNA and Protein(s)
complement receptor type 1 isoform F precursor
Status: REVIEWED
Description
Transcript Variant: This variant (F, also referred to as A) is the most common transcript. It lacks several alternate exons, compared to variant S, but maintains the reading frame. The resulting protein (F, also referred to as isoform CR1-A or CR1*1) is shorter than isoform S.
Source sequence(s)
Consensus CDS
UniProtKB/Swiss-Prot
Conserved Domains (2)
Location:1197 → 1253
CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
Location:52 → 295
PHA02927; secreted complement- Provisional
complement receptor type 1 isoform S precursor
Status: REVIEWED
Description
Transcript Variant: This variant (S, also referred to as B) represents the longer transcript and encodes the longer isoform (S, also referred to as isoform CR1-B or CR1*2).
Source sequence(s)
Consensus CDS
UniProtKB/TrEMBL
UniProtKB/Swiss-Prot
Conserved Domains (2)
Location:1647 → 1703
CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
Location:52 → 295
PHA02927; secreted complement- Provisional
The following sections contain reference sequences that belong to a
specific genome build.
Reference GRCh38.p2 Primary Assembly
NC_ Reference GRCh38.p2 Primary Assembly
mRNA and Protein(s)
Conserved Domains (2)
Location:1652 → 1708
CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
Location:57 → 300
PHA02927; secreted complement- Provisional
Conserved Domains (2)
Location:1652 → 1708
CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
Location:57 → 300
PHA02927; secreted complement- Provisional
Alternate CHM1_1.1
NC_ Alternate CHM1_1.1
Protein Accession
GenPept Link
UniProtKB Link
Blood Group Antigen Gene Mutation Database (BGMUT)
CR1 database
dbRBC Sequence Alignment Viewer
The following
resources are supplied by external providers. These providers are responsible for maintaining the links.
Interologous Interaction Database
Breast Cancer TissueBank Bioinformatics Portal
Pancreatic Expression Database
CREB Target Gene Database
Domain Mapping of Disease Mutations
FuncBase Gene Function Prediction Viewer
GenScript: ORF Clones in your selected vector
GeneNetwork
Human Gene Mutation Database
Human eFP Browser
Ingenuity Pathways Analysis
Kyoto Encyclopedia of Genes and Genomes
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs
Pharmacogenomics Knowledge Base
PhosphoSitePlus
Protein Ontology Consortium
The Gene Wiki
The Weizmann Institute of Science GeneCards and MalaCards databases
Vertebrate Genome Annotation (VEGA) database
iHOP - Information Hyperlinked over Proteins
iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
Addgene Non-profit plasmid repository
ExactAntigen/Labome
LifeSpan BioSciences, Inc.
NITE Biological Resource Center
antibodies-online
GeneWeaver
InterologFinder.org
Novus Biologicals
QIAGEN GeneGlobe
Supplemental Content
3D structure of a gene
Related PubChem BioAssays
BioAssays related to the gene by protein target or RNAi target
Summarized PubChem Data on the gene, showing the active data by default
PubChem BioAssays done on the Gene target
BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record
BioAssays that contain the gene as the target of a RNAi reagent
BioProjects related to a gene
BioSystems
Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
Related medical variations
Conserved Domain Database
Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
Link from Gene to dbVar
Link to related EST entry
Full text in PubMedCentral identified from shared sequence links
Overlapping genes and two nearest non-overlapping genes on either side
Genome records having the gene annotated on corresponding genomic reference sequence.
Related GEO
Tests for this gene in the NIH Genetic Testing Registry
Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
Related information in MedGen
Link to related Nucleotide entry
Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
Related Probe entry
Link to related protein entry
PubChem Compounds
PubChem Substances
Links between Gene and PubMed are the result of the following:
1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required.
2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
GeneRIF -- Gene Reference Into Function
Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well.
http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
Citations in PubMed identified from shared sequence and PMC links.
Link to Protein RefSeqs
Link to Nucleotide RefSeq RNAs
Link to Nucleotide RefSeqGenes
Related SNP records
SNPs linked from GeneView
Related Clinical SNP
Link to related taxonomy entry
Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
Related Variants
CR1 complement component (3b/4b) receptor 1 (Knops blood group) [Homo sapiens]Gene ID:1378
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External link. Please review our .a+3b+3c+13-2ab-4b-12c小于o a b c 为多少?他们为a+3b+3c+13-2ab-4b-12c小于o a b c 为多少?他们为整数_百度作业帮
拍照搜题，秒出答案
a+3b+3c+13-2ab-4b-12c小于o a b c 为多少?他们为a+3b+3c+13-2ab-4b-12c小于o a b c 为多少?他们为整数
a+3b+3c+13-2ab-4b-12c小于o a b c 为多少?他们为整数
（a-b）^2+2（b-1）^2+3（c-2）^2-1,abc均为整数,所以上式小于0即a=b=1,c=2