[转载]有机逆合成分析大师-Elias James Corey
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Elias James Corey (born July 12, 1928) is an
. In 1990 he won the
"for his development of the theory and methodology of ", specifically . Regarded by many as one of the greatest living chemists, he has developed numerous synthetic reagents, methodologies, and has advanced the science of
considerably.
Contents[]
E.J. Corey was born to Christian
immigrants in , 50 km (31 mi) north of Boston. His mother changed his name to "Elias" to honor his father who died eighteen months after the birth of his son. His widowed mother, brother, two sisters and an aunt and uncle all lived together in a spacious house—struggling through the depression. He attended Catholic elementary school and Lawrence Public High School.
He entered
in 1945. At , he earned both a
in 1948 and a
at age 22 in 1951. Both degrees were in chemistry. Immediately thereafter, he joined the faculty of
where he became a Full Professor of Chemistry in 1956 at the age of 27. In 1959, he moved to , where he is currently an emeritus professor of organic chemistry with an active Corey Group research program. He focuses on organic chemistry because of "its intrinsic beauty and its great relevance to human health". He has been an advisor to Pfizer for more than 50 years.
He and his wife, Claire, were married in 1961. They have three children, David, John, and Susan and two granddaughters, Sara and Kate Corey. Currently, he and his wife, Claire, live in Cambridge, Massachusetts.
In 1988, he was awarded the . He was awarded the 's greatest honor, the , in 2004.
He has developed several new synthetic reagents:
, also referred to as the Corey-Suggs reagent, and PDC (pyridinium dichromate): widely used for the oxidation of
t-Butyldimethylsilyl ether (TBDMS), Triisopropylsilyl ether (TIPS), and Methoxyethoxymethyl (MEM): popular alcohol .
Boron-based heterocycles for the asymmetric catalysis of the Diels-Alder reaction and reduction of ketones.
In addition, Corey commenced detailed studies on cationic polyolefin cyclizations utilized in enzymatic production of
from simpler plant terpenes.
Several reactions developed in Corey's lab have become commonplace in modern synthetic organic chemistry. At least 302 methods have been developed in the Corey Group since 1950. Several reactions have been named after him:
E. J. Corey and his research group have completed many . At least 265 molecules have been synthesized in the Corey Group since 1950.
His 1969 total syntheses of several
are considered classics.
Other notable syntheses:
E.J. Corey has more than 1000 publications. In 2002, the American Chemical Society (ACS) recognized him as the “Most Cited Author in Chemistry”. In 2007, he received the first ACS Publications Division “Cycle of Excellence High Impact Contributor Award” and was ranked the number one chemist in terms of research impact by the Hirsch Index ().
E.J. Corey’s books include:
E.J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis: Methods, Logic, and Practice, Direct Book Publishing LLC, 2010,
Elias James Corey, Xue-Min Cheng. The logic of chemical synthesis. Wiley-Interscience, 1995, .
E. J. Corey, Barbara Czako, Laszlo Kurti. Molecules and Medicine John Wiley & Sons, 2008.
Name reactions in heterocyclic chemistry / edited by Jie-Jack L scientific editor, E.J. Corey. Hoboken, N.J. : Wiley-Interscience, c2005.
Name reactions for functional group transformations / edited by Jie Jack Li, E.J. Corey. Hoboken, N.J. : Wiley-Interscience, c2007.
While a graduate student in Corey's research group,
committed suicide. Altom's suicide caused controversy because he explicitly blamed Corey, his research advisor, for his suicide. Corey was devastated and bewildered by Altom's death. Altom cited in his 1998 farewell note "abusive research supervisors" as one reason for taking his life. Altom's suicide note also contained explicit instructions on how to reform the relationship between students and their supervisors. As a result of Altom's death, the Department of Chemistry accepted a proposal allowing graduate students to ask two additional faculty members to play a small advisory role in preparing a thesis.
(AFSP) cited the
article on Altom's suicide as an example of problematic reporting, and suggested that Corey was unfairly scapegoated. According to , Altom's suicide note indicated fear that his career hopes were doomed, but The Globe also cited students and professors as saying that Altom actually retained Corey's support.
As of 2010, approximately 700 people have been Corey Group members. A database of 580 former members and their current affiliation was developed for Dr. Corey’s 80th birthday in July, 2008.
When awarded the
in 2004, E. J. Corey created a controversy with his claim to have inspired
prior to the development of the . Corey wrote:
“On May 4, 1964, I suggested to my colleague R. B. Woodward a simple explanation involving the symmetry of the perturbed (HOMO) molecular orbitals for the stereoselective cyclobutene → 1,3-butadiene and 1,3,5-hexatriene → cyclohexadiene conversions that provided the basis for the further development of these ideas into what became known as the Woodward-Hoffmann rules.”
This was Corey's first public statement on his claim that starting on May 5, 1964 Woodward put forth Corey’s explanation as his own thought with no mention of Corey and the conversation of May 4. Corey had discussed his claim privately with Hoffmann and close colleagues since 1964. Corey mentions that he made the Priestley statement “so the historical record would be correct".
Corey's claim and contribution were publicly rebutted by
in the journal . In the rebuttal, Hoffmann states that he asked Corey over the course of their long discussion of the matter why Corey did not make the issue public. Corey responded that he thought such a public disagreement would hurt Harvard and that he would not “consider doing anything against Harvard, to which I was and am so devoted.” Corey also hoped that Woodward himself would correct the historical record “as he grew older, more considerate, and more sensitive to his own conscience.” Woodward died suddenly of a heart attack in his sleep in 1979.
E.J. Corey has received more than 40 major awards including the
(1990), Roger Adams Award (1993), and the
(2004). As of 2008, he has been awarded 19 honorary degrees from universities around the world including
(UK), and .
&&& Corey的祖辈是来自黎巴嫩的移民。他出生不久父亲就去世了。Corey的原名叫威廉，为纪念亡父母亲把Corey的名字改为Elias。Corey在大学里面开始学的是建筑，后来被化学吸引，改学化学。看来以后又兴趣研讨有机合成的人们，应该先修建筑课程，再来从事化学合成比较好，呵呵。
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Copyright &张礼和院士出席E.J.Corey 生物医药中国（江阴）研究院揭牌典礼并作学术报告
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2013年6月29日，张礼和院士应邀出席了江苏江阴市科里生物医药中国（江阴）研究院（CIBR）揭牌典礼并做了题为“The Evolving Landscape for Drug Discovery Innovation”的报告。
E.J.Corey是哈佛大学教授、世界著名的有机化学家、有机合成的一代宗师、1990年诺贝尔化学奖得主。他和他的研究组发表了1000余篇学术论文，发明了300多种新的合成方法和200多种新试剂。他桃李满天下，截至2010年，Corey科研大家庭已达700多人。此次，Corey教授和无锡Biortus生物科技有限公司合作，在江阴市人民政府和双良集团的支持下，在江阴市建立了科里生物医药中国（江阴）研究院，于6月29日举行了揭牌典礼，并召开了学术研讨会。Corey教授发表了学术讲演。
CIBR将主要进行与药物发现有关的基础性研究并致力于将研究成果应用于新药的研发。研究方向将主要集中于国家重视的疾病领域。未来，CIBR将加大人才引进力度，吸引更多科学家加盟，以增加各学科的科研实力，努力将CIBR打造成国际知名的生物医药研究机构。
原北京大学药学院植化教研室教师，原美国拜耳公司和阿斯利康公司科学家张海军现在CIBR主持药物化学研究室，他们热切希望与药学院开展广泛的交流与合作。天然药物及仿生药物国家重点实验室王春光教授也出席了这次活动。
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&&&&&&&&&&&&&&&&& 天然药物及仿生药物国家重点实验室
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